Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting.

Comparative evaluation of novel biodegradable nanoparticles for the drug targeting to breast cancer cells.

Nanomedicine formulations such as biodegradable nanoparticles (nps) and liposomes offer several advantages over traditional routes of administration: due to their small size, nanocarriers are able to selectively accumulate inside tumours or inflammatory tissues, resulting in improved drug efficacy and reduced side effects. To further augment targeting ability of nanoparticles towards tumour cel...

Enhancement of surface ligand display on PLGA nanoparticles with amphiphilic ligand conjugates.

Biodegradable polymeric nanoparticles are widely recognized as efficacious drug delivery vehicles, yet the rational engineering of nanoparticle surfaces in order to improve biodistribution, reduce clearance, and/or improve targeting remains a significant challenge. We have previously demonstrated that an amphiphilic conjugate of avidin and palmitic acid can be used to modify poly(lactic-co-glyc...

Effect of tocopherol on Pluronic microemulsions: turbidity studies and Dynamic light scattering and dynamic surface tension measurements

The development and design of the biocompatible and biodegradable thermodynamically stable micellar and microemulsion transparent dispersions to reduce the free and unbounded drugs concentration in the blood is a basic challenge in field of drug efficacy and bioavailability of drugs. In the current work, solubilization capacity of the drug (Tocopherol), oil (Ethyl Butyrate), and oil+drug (1:1 m...

Polymeric Nanomedicines Based on Poly(lactide) and Poly(lactide-co-glycolide).

Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactid...

BIODEGRADABLE ALIPHATIC POLYESTERS for Drug Delivery POLYMERSOMES for Drug Delivery PROTEIN- AND PEPTIDE-POLYMER CONJUGATES by RAFT Polymerization FUNCTIONALIZED PEI and Its Role in Gene Therapy COLLAGEN in Gene Delivery Applications